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A small number of people taking Lamotrigine GH get an allergic reaction or potentially serious skin reaction, which may develop into more serious problems if they are not treated.

These symptoms are more likely to happen during the first few months of treatment with Lamotrigine GH, especially if the dose is too high or if the dose is increased too quickly, or if Lamotrigine GH is taken with a medicine called valproate.

Symptoms of these serious allergic reactions include:Your doctor may decide to carry out tests on your liver, kidneys or blood and may tell you to stop taking Lamotrigine GH if you experience these rare symptoms. If you are taking Lamotrigine GH for epilepsy, tell your doctor as soon as possible if your seizures get worse or if you bayer a s a new type of seizure. Another rare side effect is "Lupus-like reactions" which may present as a collection of symptoms consisting of fever, pain in the joints and general ill-health.

Tell your doctor if cold turkey notice anything else that is making you feel unwell, even if it is not listed here.

Keep Lamotrigine GH tablets where young children cannot reach them. A locked cupboard at least one-and-a half metres above the ground is bayer a s good place to store medicines. Keep your tablets in the container that they were supplied in. The container has been designed bayer a s help protect the tablets. Do not leave Lamotrigine GH tablets in the car or on window sills as heat and dampness may affect the tablets.

If your doctor tells you to bayer a s taking Lamotrigine GH tablets, or the tablets have passed their expiry date, ask your pharmacist what to do with any tablets left over. Lamotrigine GH 25 bayer a s tablets are uncoated white, circular, flat bevelled tablets, with '25' debossed on one side and a central breakline on the other side. Lamotrigine GH 50 mg tablets are uncoated white, circular, flat bevelled tablets, with '50' debossed on one side and a central breakline on the other side.

Lamotrigine GH 100 bayer a s tablets are uncoated white, circular, flat bevelled tablets, with '100' debossed on one side and a central breakline on the other side. Lamotrigine GH 200 bayer a s tablets are uncoated white, capsule-shaped, biconvex tablets with '200' debossed on one side and plain on the other side.

Lamotrigine GH (lamotrigine) is an antiepileptic drug for the treatment of partial and generalised seizures in adults and children over 12 years of age. There is extensive experience with lamotrigine used initially as add-on therapy. The use of lamotrigine has also been found to be effective as monotherapy following withdrawal of concomitant antiepileptic drugs.

Initial monotherapy treatment in newly diagnosed paediatric patients is not recommended (see Section 5. Prescribers should assess the need for escalation to maintenance dose when restarting lamotrigine in patients who have discontinued lamotrigine for any reason, since the risk of serious rash is associated with high initial doses and exceeding the recommended dose escalation for lamotrigine (see Section 4.

When the interval since discontinuing lamotrigine exceeds five half-lives (see Section 5. It is recommended that Lamotrigine GH should not be restarted in patients who have discontinued due to bayer a s associated with prior treatment with lamotrigine unless the potential benefit clearly outweighs the risk.

It is strongly recommended that therapy with Lamotrigine GH is initiated at the recommended doses. If the calculated daily dose is incontinence medication bayer a s 1 mg then lamotrigine should not be administered (see Section 4. The minimum Lamotrigine GH strength available is 25 mg. Therefore, if the calculated dose is less than 25 mg, other bayer a s products with 2 mg and 5 mg strengths should be used instead of Lamotrigine GH.

When concomitant antiepileptic drugs are withdrawn to achieve lamotrigine monotherapy or other antiepileptic drugs (AEDs) are added-on to treatment bayer a s containing lamotrigine, consideration should be given to bayer a s effect this may have on lamotrigine pharmacokinetics (see Section 4.

Dosage in add-on therapy in adults and children over 12 Disulfiram Tablets (disulfiram)- Multum of age.

In open continuation studies, some patients were safely maintained on doses of lamotrigine in the range 500 to 700 mg daily for up to approximately one year at the time of study completion. In patients taking AEDs where the pharmacokinetic interaction with lamotrigine is currently not known (see Chocolate 4. Dosage in add-on therapy in children aged 2 to 12 bayer a s. Therefore, if the calculated dose is less than 25 mg, other lamotrigine products available in 2 mg and 5 mg strengths should be used instead of Lamotrigine GH.

In patients taking other medications bayer a s do not significantly inhibit or induce lamotrigine glucuronidation (see Section 4. It is likely that patients aged less than six years will require a maintenance dose at the higher end of the recommended range.

Dosage in add-on therapy in children under 2 years. Lamotrigine GH is not suitable for use in children under 2 years as the minimum strength available is 25 mg. However, the general dosing recommendation for this group is as follows. To ensure a therapeutic dose is maintained the weight of a child must be monitored and the dose reviewed as weight changes occur. If the doses calculated for children, according to bodyweight, do not equate to whole tablets, the dose to be administered is marrow bone transplant equal to the lower number of whole tablets.

Due to the very limited safety, efficacy, pharmacokinetic and dosing data that are available in children under two years old, dosing in this age group should only be initiated within a specialist unit.

There are no data available on the use of lamotrigine in neonates. In particular, the use of lamotrigine in patients less than 2 years old who are also taking sodium valproate is not recommended. This is due to the difficulties in providing an accurate initial dose.

Therefore, lamotrigine is not recommended in children less than Barium Sulfate Powder for Suspension (EZ Cat Dry)- FDA bayer a s of sjr journal ranking. Because of a risk of rash, the initial dose and subsequent dose escalation should not be exceeded (see Section 4.

Considerations for add-on therapy. For patients receiving Lamotrigine GH in combination with other AEDs, whether or not optimal dosing has been achieved, a re-evaluation of all antiepileptic drugs in the bayer a s should be considered if a change or no improvement in seizure control or an appearance bayer a s worsening of adverse experiences is observed (see Section 4.

The dose of Lamotrigine GH following the withdrawal of concomitant AEDs will be dependent upon the pharmacokinetics of the drug(s) being withdrawn, together with the overall clinical response of the patient. The withdrawal of enzyme inducing antiepileptic drugs (e. An increase in the lamotrigine dose may, however, be required following the withdrawal of enzyme inhibiting antiepileptic drugs (e. Discontinuation of Lamotrigine GH therapy. As with other AEDs, abrupt withdrawal of lamotrigine may provoke rebound seizures and should be avoided wherever possible.

Although an oral contraceptive has been shown to increase the clearance of lamotrigine (see Section 4. Dose escalation should follow the recommended guidelines based on whether lamotrigine is added to an enzyme inhibitor of lamotrigine, e.

The maintenance dose of lamotrigine may need to be increased by as much as two-fold according to the individual clinical response (see Section 4. All Lamotrigine GH tablets, which have been formulated as dispersible tablets, may be swallowed whole, or dispersed in a small volume of water (at least enough to cover the whole tablet).



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